Maternal health and perinatal medicine are population health challenges which are in need of innovation. Preeclampsia and its sequela of eclampsia are among the most common reasons for maternal and perinatal morbidity, mortality and premature birth causing great human suffering and very high economic cost. Comanche is developing a novel treatment for preeclampsia with the goal of lowering the risks of poor birth outcomes, increasing the chances of the pregnancy reaching full term.